University of Minnesota Chemists Pioneer Blue Light Method for Drug and Agrochemical Discovery
University of Minnesota chemists developed a new method using low-energy blue light to create complex molecules for pharmaceuticals and agrochemicals, eliminating wasteful additives. The technique, published in Nature, enables faster, cost-effective, and energy-efficient synthesis of essential chemical precursors.
A team of organic and computational chemists at the University of Minnesota Twin Cities has created a novel method for synthesizing complex molecules crucial for drug and agrochemical discovery. Their approach uses low-energy blue light, such as that from common aquarium lights, to activate chemical reactions, removing the need for wasteful additives previously required. This advancement, detailed in a recent Nature publication, centers on aryne intermediates, which serve as building blocks for complex molecules. The method was accelerated by computational modeling and organic chemistry, allowing researchers to understand the molecular changes at the atomic level. The new technique is not only more sustainable but also opens up possibilities for applications in biological conditions and advanced drug discovery processes. The team has already developed about 40 building blocks and aims to expand this set for broader scientific use. The research was supported by various grants and awards, and the full paper is available in Nature.
