Zaiput Launches KryZr Continuous Crystallizer for Advanced Antisolvent and Cooling Crystallization

Published By DPRJ Universal | Published on Thursday, 11 December 2025

Zaiput Flow Technologies has launched KryZr, a next-generation continuous crystallizer designed for antisolvent and cooling crystallization processes. This advanced platform aims to revolutionize pharmaceutical and fine chemical manufacturing by offering superior control, improved crystal quality, and significantly lower R&D costs. Key features include a proprietary A-PUSH Slurry Transfer System and efficient temperature control. KryZr allows for greatly reduced material needs during development, marking a significant step in transitioning from batch to continuous processes.

Zaiput Flow Technologies proudly announced the commercialization of its innovative Continuous Crystallizer, KryZr, on December 11, 2025. Developed in Waltham, MA, KryZr is engineered to significantly enhance both cooling and antisolvent crystallization processes, primarily targeting the pharmaceutical and fine chemical sectors. This state-of-the-art platform represents a substantial advancement in crystallization technology, emphasizing efficiency, precise control, and scalability, even at a lab scale volume of just 86 mL.KryZr introduces several groundbreaking features designed to optimize manufacturing. Its proprietary A-PUSH Slurry Transfer System, combined with nonreturn valves, ensures plug-flow characteristics for both liquid and solids, enabling isokinetic withdrawal without transfer lines between tanks. This meticulous design contributes to improved crystal quality attributes through highly efficient mixing, precise temperature control, and the capability to distribute antisolvent into any tank within the cascade. A significant benefit of KryZr is the drastic reduction in development costs, as it minimizes the amount of material required for crystallization process development.Dr. Andrea Adamo, Zaiput's CEO, highlighted that KryZr aligns with the company's commitment to delivering tools that facilitate the transition from batch to continuous manufacturing. Mr. Robert Viano, KryZr Product Manager, added that the technology will revolutionize multistage continuous crystallizations, leading to greatly reduced costs in API crystallization development. Zaiput invites researchers and scientists to explore KryZr's potential by visiting their website or contacting their sales team.